Resident Evil 4's Pro Mode campaign can be daunting for some. After the success of my Mercenary guides, many people asked me to create a general Pro Mode guide.
In this video I explain useful strategies and tricks to improve your gameplay. I show you the best ways to deal with each boss and do important battles against the normal enemies.
This video also includes the locations of all treasures as well as the shooting gallery challenges to help collect money for weapons and their respective upgrades.
Speaking of weapons, I also offer you a weapon roadmap that shows you what you should and shouldn't upgrade depending on your preferences.
This guide is not exhaustive and does not cover every single battle in the game, but I hope it explains everything well enough to help those who are struggling and maybe teach players a few new things they don't know.
You'll find timestamps of the key moments below so you can jump straight to the part you need, but I recommend checking out the entire guide.

00:00 – Introduction
02:10 – First village fight
06:36 – Canyon Battle
13:00 – Del Lago fight
15:15 – Fight El Gigante
18:20 – Locker room fight
19:36 – 2nd Gigante fight
20:20 – Battle of the Chainsaw Sisters
22:15 – Boss fight against Chief Mendez
24:50 – The Castle
26:21 – Sword Room
28:05 – Garrador Battle
28:55 – Water space battle
30:53 – Shooting range A
32:13 – Newcomers 1
35:53 – Praying Cultists
37:18 – Minigun Zealot
39:26 – Salazar Ambush
40:20 – The Labyrinth
42:50 – Garrador Cage
44:16 – Ashley’s escape
45:41 – Backtrack for Broken Butterfly
46:47 – Lava Room
47:54 – Shooting range B
48:33 – Knight
50:57 – Newcomers 2
54:27 – Double Garrador
56:18 – Verdugo boss fight
56:52 – Shooting Range C
57:48 – The Mines
59:44 – Two giants
01:01:05 – Novistadores 3 (Caves)
01:02:55 – Mines 2
01:06:03 – Minecart Battle
01:08:07 – Salazar Statue
01:10:23 – Castle Tower
01:11:21 – Salazar boss fight
01:12:28 – The Island
01:12:46 – First JJ
01:17:17 – Shooting range D
01:18:52 – Regenerators 1
01:20:14 – Thermal imaging device
01:21:45 – Iron Maiden
01:23:10 – Wrecking Ball Room
01:24:15 – Regenerators 2
01:24:25 – Demolition truck
01:25:59 – It's a boss fight
01:31:27 – Krauser boss fight
01:33:30 – Mike (helicopter) fights
01:38:58 – Last regenerator
01:39:39 – Third JJ and final Ganado attack
01:43:23 – Saddler boss fight
01:47:05 – Closing remarks and greetings

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